Science Blog

The blood-brain barrier lets glucose and ketones cross freely, but blocks 98% of small-molecule drugs — and the tight junctions doing the filtering are only about 4 nanometers wide

The blood-brain barrier lets glucose and ketones c...

The endothelial cells lining brain capillaries are stitched together by tight junctions only 4 nanom...
When researchers presenting at the Alzheimer’s Association International Conference this week described a blood test that flags people 5 to 10 years before symptoms appear, they were reporting on a panel of plasma biomarkers that correctly predicted cognitive decline in roughly 90 percent of participants tracked across a decade.

When researchers presenting at the Alzheimer’s Ass...

New research presented at the Alzheimer's Association International Conference shows plasma biomarke...
In April 1967, a Palo Alto history teacher named Ron Jones invented a classroom movement called The Third Wave and shut it down on day five when 200 students showed up in uniform expecting a national leader

In April 1967, a Palo Alto history teacher named R...

In April 1967, Cubberley High School history teacher Ron Jones set out to show his class how ordinar...
A single cup of raw spinach delivers about 750 milligrams of oxalic acid — a plant defense compound potent enough to crystallize in human kidneys and bind calcium out of the bloodstream

A single cup of raw spinach delivers about 750 mil...

Spinach's oxalic acid is a genuine plant defense compound — one that binds calcium in the gut, cryst...
Astronauts lose roughly 1% of their bone mineral density every month in orbit — a rate that outpaces severe osteoporosis on Earth by more than tenfold

Astronauts lose roughly 1% of their bone mineral d...

Astronauts shed roughly 1% of their bone mineral density per month in orbit — more than ten times th...
Sardinian shepherds in the Ogliastra highlands carry a rare variant of the M26 Y-chromosome haplogroup found almost nowhere else on Earth, and geneticists think 10,000 years of mountain isolation is why the island produced so many centenarians

Sardinian shepherds in the Ogliastra highlands car...

In Sardinia's Ogliastra highlands, shepherds carry a Y-chromosome lineage — haplogroup I2a1a-M26 — t...
NASA just paid three private companies $600 million to land on the Moon four times in 2028 — and the identical instruments they’re carrying reveal what the agency is really building toward

NASA just paid three private companies $600 millio...

NASA has committed nearly $600 million to three commercial space companies for four robotic Moon lan...
Rest and holidays, we assume, are what happiness is made of — yet the psychologist who spent decades studying it suggested the satisfaction we’re chasing might follow the opposite: hard, absorbing work where challenge meets skill and the self dissolves into the task, a state he called ‘flow

Rest and holidays, we assume, are what happiness i...

Ask people what would make them happier and the answer is usually the same: time off, fewer demands,...
In 2011, Peruvian geologist Andrés Ruzo followed his grandfather’s story into the Amazon and confirmed a 6.4-kilometre stretch of river that runs at 86 degrees Celsius with no volcano within 700 kilometres, hot enough to cook small animals that fall in.

In 2011, Peruvian geologist Andrés Ruzo followed h...

In 2011, geophysicist Andrés Ruzo confirmed a 6.24-kilometre stretch of the Peruvian Amazon's Shanay...
Margaret Hamilton was 32 years old when her Apollo 11 flight software began throwing 1202 alarms during the lunar descent, and the priority-scheduling system she had insisted on building — over objections that it was overkill — silently shed low-priority tasks and let Armstrong land with less than 30 seconds of fuel to spare.

Margaret Hamilton was 32 years old when her Apollo...

On July 20, 1969, the Apollo Guidance Computer began flashing 1202 alarms as Eagle descended toward ...
The Mariana snailfish lives 8,000 metres down in water that would crush a submarine, and its skeleton is made mostly of cartilage flooded with a molecule called TMAO that keeps its proteins from folding under the weight of the ocean above it.

The Mariana snailfish lives 8,000 metres down in w...

The Mariana snailfish thrives 8,000 metres down in water pressure that would crush a submarine — tha...
The International Space Station loses about 100 meters of altitude a day and must be shoved back up by a docked Russian thruster roughly once a month to keep from falling

The International Space Station loses about 100 me...

The 420-tonne International Space Station sinks about 100 meters a day through the thin upper atmosp...
Vitamin B12 exists nowhere in the plant kingdom — it is synthesized only by bacteria and archaea, and every animal that needs it either eats microbes or eats something that did

Vitamin B12 exists nowhere in the plant kingdom — ...

Vitamin B12 is the only vitamin that no plant and no animal can synthesise. Every microgram in the f...
Skeletal muscle burns through its entire ATP supply in about two seconds of hard effort, and a backup molecule stored at roughly 120 millimoles per kilogram is what keeps the sprint going

Skeletal muscle burns through its entire ATP suppl...

Skeletal muscle stores only enough ATP for about two seconds of maximal effort. A phosphocreatine re...
The 2,700 heatwave deaths in England this summer weren’t really about the heat — they were about a housing stock built for a country that no longer exists

The 2,700 heatwave deaths in England this summer w...

json { “content”: “ The two heatwaves that seared England and Wales in May and June killed roughly 2...
Tree swallows nesting at the northern edge of their range are collapsing faster than southern populations — and the culprit isn’t warming, it’s the widening whiplash of spring temperatures pulling nests out of sync with the insects they need to feed chicks

Tree swallows nesting at the northern edge of thei...

Tree swallows breeding at the northern edge of their range are paying a steeper climate penalty than...
In 2017, a single lightning bolt stretched an incredible 829 kilometres from Texas to Missouri, setting a mind-boggling world record for the longest continuous flash ever captured on Earth

In 2017, a single lightning bolt stretched an incr...

On 29 April 2020, a single stroke of lightning stretched 768 kilometres across Texas, Louisiana, and...
In 1665, Robert Hooke pressed a sliver of cork under his handmade microscope, saw thousands of tiny empty compartments that reminded him of the rooms monks slept in, and christened them cells in a folio called Micrographia that Samuel Pepys stayed up all night reading.

In 1665, Robert Hooke pressed a sliver of cork und...

In January 1665, Robert Hooke peered through a leather-covered microscope at a shaving of cork, saw ...

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